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KMID : 0603820120180030283
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Journal of Experimental & Biomedical Science
2012 Volume.18 No. 3 p.283 ~ p.290
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Virological Characteristics in Chronic Hepatitis B Patients with Concurrent HBsAg and anti-HBs Positivity
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Lee Hyeok-Jae
Lee Min-Hyeok
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Abstract
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In this study, we investigated the virological characteristics, HBV DNA levels and presence of mutations of "a" determinant in the HBsAg S gene in chronic hepatitis B patients with coexisting HBsAg and anti-HBs. The 18 patients who were diagnosed with chronic hepatitis B were both positive for HBsAg and anti-HBs. HBV Among them, 15 patients were DNA positive. The median of HBV DNA levels in serum was 2.18×107 copies/mL with the HBsAg+/anti-HBsAb+ patients. Also, 4 of 8 HBeAg negative patients had HBV DNA levels higher than 104 copies/mL and the median of HBV DNA levels was 2.03×106 copies/mL, which were significantly high. These results showed that viral replication still existed in most of the patients of the concomitant HBsAg and anti-HBs, and even in the some HBeAg negative patients. Furthermore, mutation within the "a" determinant of HBV were found in 7 of 15 patients. The most frequent changes were located at positions aa126. In addition, one mutation observed for HBsAg only positive.
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KEYWORD
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HBV, HBsAg, Anti-HB, HBeAg, HBV DNA, "a" determinant, Mutation
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